Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Zero-order controlled-release polymer matrices for micro- and macromolecules.

D S Hsieh, W D Rhine, R Langer

    Journal of Pharmaceutical Sciences
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Redistribution of androgen receptors in acquired hormone-refractory prostate cancer cells.

    Archives of andrology·2006
    Same author

    Increasing expression of GST-pi MIF, and ID1 genes in chemoresistant prostate cancer cells.

    Archives of andrology·2006
    Same author

    Modulation of MDR-1 gene by MIF and GSTpi with drug resistance generation in hormone independent prostate cancer.

    Archives of andrology·2006
    Same author

    The expression of neuropeptides in hyperplastic and malignant prostate tissue and its possible clinical implications.

    The Journal of urology·2001
    Same author

    Detection of chromosomal alterations in bladder cancer by comparative genomic hybridization.

    BJU international·2001
    Same author

    Bilateral idiopathic infantile pyoceles: a case report.

    Zhonghua yi xue za zhi = Chinese medical journal; Free China ed·1998
    Same journal

    Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

    Journal of pharmaceutical sciences·2026
    Same journal

    Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

    Journal of pharmaceutical sciences·2026
    Same journal

    Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

    Journal of pharmaceutical sciences·2026
    Same journal

    Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

    Journal of pharmaceutical sciences·2026
    Same journal

    A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

    Journal of pharmaceutical sciences·2026
    Same journal

    Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

    Journal of pharmaceutical sciences·2026
    See all related articles

    This study developed a novel hemispheric polymer-drug matrix system for controlled drug delivery. The innovative design achieves zero-order drug release kinetics, ensuring consistent medication dosage over an extended period.

    Area of Science:

    • Materials Science
    • Pharmaceutical Sciences
    • Biomedical Engineering

    Background:

    • Controlled drug delivery systems are crucial for maintaining therapeutic drug concentrations.
    • Achieving zero-order release kinetics, a constant drug release rate, remains a significant challenge in pharmaceutical formulation.
    • Polymer-drug matrices offer potential for sustained drug release but often struggle with predictable kinetics.

    Purpose of the Study:

    • To design and evaluate a novel hemispheric polymer-drug matrix system.
    • To achieve zero-order release kinetics for both low and high molecular weight drugs.
    • To demonstrate sustained drug release over an extended period using this innovative matrix design.

    Main Methods:

    • Fabrication of hemispheric polymer-drug matrices using polyethylene for low molecular weight drugs (sodium salicylate) via compression molding.

    Related Experiment Videos

  • Preparation of hemispheric systems for high molecular weight drugs (bovine serum albumin) using ethylene-vinyl acetate copolymer via low-temperature casting and multi-step drying.
  • Application of an impermeable coating to the matrices, leaving a central exposed cavity to control drug release.

    • Main Results:

    • Successful fabrication of hemispheric polymer-drug matrices for both low and high molecular weight drugs.
    • Demonstrated zero-order release kinetics from the developed systems.
    • Achieved a sustained release rate of 0.5 mg/day for 60 days from polymer matrices containing bovine serum albumin (68,000 mol. wt.).

    Conclusions:

    • The developed hemispheric polymer-drug matrix system with a central cavity and impermeable coating is effective in achieving zero-order drug release.
    • This innovative drug delivery system shows promise for long-term, controlled release of various molecular weight drugs.
    • The findings support the potential of this technology for advanced pharmaceutical applications requiring precise drug administration.