Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic lupus erythematosus and IgA deficiency.

V Yewdall, J S Cameron, A W Nathan

    Journal of Clinical & Laboratory Immunology
    |January 1, 1983
    PubMed
    Summary

    Immunoglobulin A (IgA) deficiency is significantly more common in patients with systemic lupus erythematosus (SLE), particularly those with nephritis. This suggests a potential link between IgA deficiency and SLE development or progression.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Age-growth relationships, temperature sensitivity and palaeoclimate-archive potential of the threatened Altiplano cactus <i>Echinopsis atacamensis</i>.

    Conservation physiology·2021
    Same author

    Drought response of a native and introduced Hawaiian grass.

    Oecologia·2017
    Same author

    Impacts of warming and elevated CO2 on a semi-arid grassland are non-additive, shift with precipitation, and reverse over time.

    Ecology letters·2016
    Same author

    Training and the European Working Time Directive: a 7 year review of paediatric anaesthetic trainee caseload data.

    British journal of anaesthesia·2009
    Same author

    Sprayable microencapsulated sex pheromone formulation for mating disruption of oriental fruit moth (Lepidoptera: Tortricidae) in Australian peach and pear orchards.

    Journal of economic entomology·2007
    Same author

    The sensitivity of ecosystem carbon exchange to seasonal precipitation and woody plant encroachment.

    Oecologia·2006

    Area of Science:

    • Nephrology
    • Immunology
    • Rheumatology

    Background:

    • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs.
    • IgA deficiency is a primary immunodeficiency, the most common globally.
    • The relationship between IgA deficiency and SLE, especially lupus nephritis, requires further investigation.

    Observation:

    • A survey of 138 SLE patients (113 with nephritis) was conducted.
    • Four SLE patients exhibited IgA deficiency, with one experiencing prolonged deficiency post-phenytoin treatment.
    • In contrast, only one patient among 342 controls (random hospital patients and idiopathic glomerulonephritis patients) had IgA deficiency.

    Findings:

    • The prevalence of IgA deficiency in SLE patients, particularly those with nephritis, is approximately 20 times higher than in the general population.

    Related Experiment Videos

  • This elevated association suggests a specific link between IgA deficiency and SLE pathogenesis.
  • A single case of IgA deficiency was noted in minimal change nephrotic syndrome.

    • Implications:

    • The findings suggest a potential role for IgA deficiency in the development or exacerbation of SLE and lupus nephritis.
    • Possible underlying mechanisms include defective T-cell regulation or impaired immune complex clearance.
    • Further research into the immunological interplay between IgA deficiency and SLE is warranted.