Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain histamine-plasma corticosterone interactions.

I M Mazurkiewicz-Kwilecki

    Life Sciences
    |March 7, 1983
    PubMed
    Summary
    This summary is machine-generated.

    This study shows that central histamine (HA) plays a role in endocrine function. Administering corticosterone or L-histidine significantly altered HA levels in rat brains, impacting plasma corticosterone.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Changes in the regional brain histamine and histidine levels in postmortem brains of Alzheimer patients.

    Canadian journal of physiology and pharmacology·1989
    Same author

    Brain histamine response to stress in 12 month old rats.

    Life sciences·1986
    Same author

    Brain histamine regulation following chronic diazepam treatment and stress.

    Pharmacology, biochemistry, and behavior·1986
    Same author

    Possible role of histamine in brain function: neurochemical, physiological, and pharmacological indications.

    Canadian journal of physiology and pharmacology·1984
    Same author

    Age-related changes in brain histamine.

    Agents and actions·1984
    Same author

    Effect of diphenhydramine on stress-induced changes in brain histidine decarboxylase activity, histamine and plasma corticosterone levels.

    Pharmacology, biochemistry, and behavior·1982
    Same journal

    Steroidal alkaloid H89712 ameliorates neuroinflammation and memory deficits: Enhancing cerebral oxidative phosphorylation in APP/PS1 mice.

    Life sciences·2026
    Same journal

    Targeting PARP1-dependent parthanatos in Alzheimer's disease: Mechanisms and therapeutic opportunities.

    Life sciences·2026
    Same journal

    The emerging role of NAT10-mediated N4-acetylcytidine modification of RNA in bone diseases: Current frontiers and future challenges.

    Life sciences·2026
    Same journal

    Overactivated bradykinin-B2 receptor promotes type a aortic dissection by inducing endothelial dysfunction: Therapeutic effect of icatibant.

    Life sciences·2026
    Same journal

    Gut microbiota and metabolites in remodeling the tumor microenvironment and regulating immunotherapeutic efficacy in colorectal cancer.

    Life sciences·2026
    Same journal

    A CD31-derived cytoplasmic ITIM peptide enhances epidermal and dermal regeneration in cutaneous wound repair.

    Life sciences·2026
    See all related articles

    Area of Science:

    • Neuroendocrinology
    • Biochemistry

    Background:

    • Histamine (HA) is a neurotransmitter with known roles in various physiological processes.
    • The involvement of central histamine in regulating endocrine functions, particularly the hypothalamic-pituitary-adrenal (HPA) axis, remains an area of active investigation.

    Purpose of the Study:

    • To investigate the effect of exogenous corticosterone on central histamine levels in rats.
    • To examine the impact of L-histidine administration on both central histamine and plasma corticosterone levels.
    • To explore the role of central histamine in the regulation of endocrine function.

    Main Methods:

    • Rats were administered corticosterone (2.4 mg/kg, i.p.) or L-histidine (500 mg/kg, i.p.).
    • Plasma corticosterone and brain histamine levels (hypothalamus, midbrain, cortex) were measured at various time points post-administration.

    Related Experiment Videos

    Main Results:

    • Corticosterone administration rapidly increased hypothalamic histamine levels, with effects lasting up to 60 minutes.
    • L-histidine administration significantly elevated histamine levels in the hypothalamus, midbrain, and cortex for up to 10 hours.
    • Elevated brain histamine levels, particularly in the hypothalamus, were associated with a significant and prolonged increase in plasma corticosterone levels.

    Conclusions:

    • Central histamine, especially within the hypothalamus, is implicated in the regulation of the HPA axis and endocrine function.
    • Histaminergic pathways in the brain can influence corticosterone secretion.
    • These findings highlight a potential neurochemical link between histamine signaling and stress hormone regulation.