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Protein-losing enteropathy in systemic lupus erythematosus
The American Journal of Gastroenterology
|March 1, 1983
Summary
Protein-losing enteropathy, a rare complication of systemic lupus erythematosus, can be the sole presenting symptom. This condition, characterized by intestinal edema, responded well to corticosteroid treatment, suggesting its importance in unexplained hypoalbuminemia.
Area of Science:
- Gastroenterology
- Rheumatology
- Internal Medicine
Background:
- Protein-losing enteropathy (PLE) is a rare condition characterized by excessive loss of plasma proteins into the gastrointestinal tract.
- While associated with various conditions, PLE is infrequently reported with systemic lupus erythematosus (SLE).
Observation:
- This report details a case where PLE was the exclusive clinical manifestation of SLE.
- Small intestinal biopsy showed edema and mild mononuclear cell infiltration in the lamina propria mucosae.
- Gastrointestinal X-ray studies were unremarkable, and no lymphangiectasia was observed.
Findings:
- The patient's PLE responded effectively to high-dose corticosteroid therapy.
- This suggests a potential autoimmune or inflammatory basis for the enteropathy in this SLE patient.
Implications:
- Clinicians should consider PLE in SLE patients presenting with unexplained hypoalbuminemia.
- Early recognition and treatment of PLE may improve outcomes in systemic lupus erythematosus management.