Feeding after recovery from 2-deoxyglucose injection: cerebral and peripheral factors

Rats increased food intake 6 h after peripheral and intracerebroventricular injections of 2-deoxy-D-glucose (2-DG) when plasma glucose concentrations had returned to normal from elevated levels. Rats with adrenal demedullation did not become hyperglycemic after injection of 2-DG and increased food intake more than normal animals after peripheral, but not ventricular, injections of 2-DG. Peripheral injections of 2-DG inhibited gastric emptying in normal, but not adrenal demedullated, rats. Intravenous infusions of epinephrine into normal rats, which mimicked some of the physiological effects of peripheral 2-DG injection, did not increase food intake. The results indicate that a prior disruption of cerebral metabolism is sufficient to elicit feeding in the absence of an adrenomedullary response and that increased gastric fill may restrain the increase in food intake produced by a previous cerebral emergency.