Related Experiment Video
Updated: Jul 25, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Abstract:
Fifty-two patients with unexplained pulmonary symptoms were tested using inhaled methacholine. Of the 32 who reacted 11 had a greater than 20% decrease in FEV1 (with or without an associated change in FEF25-75%) as the end-point, 15 had a greater than 25% decrease in FEF25-75% as their initial response while 6 had an initial greater than 25% decrease in FEF200-1200. In some but not all subjects in the latter two groups a decrease in FEV1 occurred with increased methacholine concentrations. Changes in FEF25-75% and FEF200-1200 should be considered in documentation of airway hyperreactivity in some patients.
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