Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of amiloride and furosemide on histamine release from human leukocytes induced by anti-IgE antibody.

The Journal of allergy and clinical immunology·1992
Same author

Egg-derived vaccines.

Annals of allergy·1991
Same author

Effects of histamine on alpha adrenergic receptor expression on the lymphocytes of normal and asthmatic subjects.

Annals of allergy·1990
Same author

Pharmacist substitution of slow-release theophylline products.

The Journal of allergy and clinical immunology·1989
Same author

Effect of an inhaled corticosteroid on methacholine airway reactivity.

The Journal of allergy and clinical immunology·1981
Same author

The value of atropine in the documentation of reversible airways obstruction.

Annals of allergy·1979

Related Experiment Video

Updated: Jul 25, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Patterns of response to inhaled methacholine.

J G Easton

    Annals of Allergy
    |March 1, 1983
    PubMed
    Summary

    Methacholine challenge tests help diagnose airway hyperreactivity. Measuring changes in forced expiratory flow rates (FEF25-75% and FEF200-1200) alongside forced expiratory volume in one second (FEV1) improves diagnostic accuracy.

    Area of Science:

    • Pulmonary Medicine
    • Respiratory Physiology

    Background:

    • Unexplained pulmonary symptoms often warrant investigation for airway hyperreactivity.
    • Methacholine challenge testing is a standard method to assess bronchial responsiveness.

    Purpose of the Study:

    • To evaluate the utility of different endpoints in methacholine challenge testing for diagnosing airway hyperreactivity.
    • To determine if changes in forced expiratory flow rates (FEF) are valuable indicators of bronchial hyperresponsiveness.

    Main Methods:

    • Fifty-two patients with unexplained pulmonary symptoms underwent inhaled methacholine challenge testing.
    • Responses were categorized based on percentage decrease in forced expiratory volume in one second (FEV1), forced expiratory flow rate between 25% and 75% of vital capacity (FEF25-75%), and forced expiratory flow rate between 200 mL and 1200 mL (FEF200-1200).

    More Related Videos

    Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
    13:10

    Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

    Published on: May 15, 2013

    Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
    08:58

    Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

    Published on: July 10, 2018

    Related Experiment Videos

    Last Updated: Jul 25, 2026

    Murine Model of Allergen Induced Asthma
    08:05

    Murine Model of Allergen Induced Asthma

    Published on: May 14, 2012

    Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
    13:10

    Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

    Published on: May 15, 2013

    Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
    08:58

    Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

    Published on: July 10, 2018

    Main Results:

    • Thirty-two patients exhibited a positive methacholine challenge.
    • Specific response patterns included decreases in FEV1 (n=11), FEF25-75% (n=15), and FEF200-1200 (n=6).
    • FEV1 decline was observed in some patients with initial FEF changes, indicating variable response patterns.

    Conclusions:

    • Changes in FEF25-75% and FEF200-1200 are significant indicators of airway hyperreactivity.
    • Incorporating FEF measurements alongside FEV1 enhances the documentation and diagnosis of bronchial hyperresponsiveness in patients with pulmonary symptoms.