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Progressive chloroquine retinopathy.

J W Sassani, A J Brucker, W Cobbs

    Annals of Ophthalmology
    |January 1, 1983
    PubMed
    Summary
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    Chloroquine retinopathy, a toxic side effect, can manifest years after medication use. This case highlights delayed onset and progression of bull's-eye maculopathy, confirmed by fluorescein angiography.

    Area of Science:

    • Ophthalmology
    • Toxicology

    Background:

    • Chloroquine is a widely used systemic medication.
    • Chloroquine retinopathy is a known toxic side effect.
    • Retinal findings include macular changes, narrowed vessels, and visual field defects.

    Observation:

    • A patient developed mild macular changes two years after discontinuing chloroquine.
    • Over nine years, progressive vision loss occurred.
    • Repeated fluorescein angiograms documented evolving bull's-eye maculopathy.

    Findings:

    • The patient's condition was consistent with chloroquine retinopathy.
    • No hereditary macular dystrophy was found in offspring.
    • This is the first reported case of delayed-onset, progressive chloroquine maculopathy.

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    Implications:

    • This case underscores the potential for delayed and progressive chloroquine retinopathy.
    • Ophthalmologists should consider long-term monitoring for patients using chloroquine.
    • Fluorescein angiography is crucial for diagnosing and monitoring this condition.