Vitamin E retards the lipoperoxidation resulting from anticancer drug administration

The administration of either 5-fluorouracil, methotrexate, cyclophosphamide or vincristine to rats produced an increase in liver and plasma, but not brain, lipoperoxide levels. There was no significant difference between the glutathione peroxidase activity in the liver and the brain tissue of cytotoxic drug-treated and control rats. Glutathione peroxidase activity was significantly lower in the erythrocytes of 5-fluorouracil-and methotrexate-treated rats than in control animals. The erythrocyte glutathione peroxidase levels of vincristine- and cisplatin-treated rats did not differ significantly from the control levels. Rats which received vitamin E supplementation concomitantly with 5-fluorouracil treatment had liver and plasma lipoperoxide levels which were significantly lower than those which had received only the anticancer drug. The tissue lipoperoxide levels in the vitamin E supplemented, 5-fluorouracil-treated rats were comparable with those of arachis oil-treated controls.