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Nafcillin-induced platelet dysfunction and bleeding.

D P Alexander, M E Russo, D E Fohrman

    Antimicrobial Agents and Chemotherapy
    |January 1, 1983
    PubMed
    Summary
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    Nafcillin antibiotic can cause platelet dysfunction and bleeding issues. This study highlights nafcillin as a potential cause of abnormal bleeding times and impaired platelet aggregation.

    Area of Science:

    • Pharmacology
    • Hematology
    • Internal Medicine

    Background:

    • Antibiotics are widely used, but some can cause adverse effects.
    • Platelet dysfunction can lead to significant bleeding complications.

    Observation:

    • Two cases of nafcillin-induced platelet dysfunction are presented.
    • One patient showed positive rechallenge data confirming nafcillin's role.

    Findings:

    • Nafcillin administration resulted in abnormal bleeding times in both patients.
    • Platelet aggregation studies revealed impaired responses to ADP, collagen, and epinephrine.
    • Platelet count and morphology remained normal, indicating a functional defect.

    Implications:

    • Nafcillin should be recognized as a potential cause of antibiotic-associated platelet dysfunction.

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  • Clinicians should consider nafcillin when evaluating patients with unexplained bleeding episodes.
  • Awareness of this adverse effect can improve patient safety and management.