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Loperamide in severe protracted diarrhoea.

B K Sandhu, J H Tripp, P J Milla

    Archives of Disease in Childhood
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Loperamide effectively treated severe infant diarrhea by reducing intestinal fluid secretion. This drug offers a crucial new option for infants unresponsive to other treatments, demonstrating significant antisecretory effects.

    Area of Science:

    • Pediatric Gastroenterology
    • Pharmacology

    Background:

    • Protracted diarrhea in infants poses a severe, life-threatening challenge.
    • Current treatments for severe infant diarrhea are often ineffective.

    Observation:

    • Six infants with severe protracted diarrhea were treated with loperamide.
    • Jejunal perfusion studies indicated a net secretory state for water in two infants.
    • Persistent diarrhea despite nil by mouth suggested secretory states in other infants.

    Findings:

    • Loperamide treatment led to rapid and significant improvement in all six infants.
    • The drug demonstrated an antisecretory action on the small intestine.
    • Two infants showed a net secretory state for water in the jejunum.

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    Implications:

    • Loperamide is a valuable therapeutic option for managing refractory protracted diarrheal states in infants.
    • The drug's antisecretory properties are key to its efficacy.
    • Further research into loperamide's role in pediatric gastroenterology is warranted.