Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Exogenous hyperthyroidism with osteoporosis.

M D Fallon, H M Perry, M Bergfeld

Archives of Internal Medicine

|March 1, 1983

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Screening for Vitamin D Deficiency in Black Americans: Comparison of Total, Free, Bioavailable 25 Hydroxy Vitamin D Levels with Parathyroid Hormone Levels and Bone Mineral Density.

The journal of nutrition, health & aging·2018

Same author

Tumours of Gut Wall (due to Galoncus perniciosus) showing Relation of Helminth Infection to Bacterial Invasion of the Tissues.

Proceedings of the Royal Society of Medicine·2009

Same author

Some Observations on the Occurrence of Leishmania in the Intestinal Tissues in Indian Kala-Azar; on the Pathological Changes occasioned by their Presence, and on their possible Significance in this Situation.

Proceedings of the Royal Society of Medicine·2009

Same author

Higher C-reactive protein and soluble tumor necrosis factor receptor levels are associated with poor physical function and disability: a cross-sectional analysis of a cohort of late middle-aged African Americans.

The journals of gerontology. Series A, Biological sciences and medical sciences·2009

Same author

Comparison of screening questionnaires for the diagnosis of hypogonadism.

Maturitas·2005

Same author

Testosterone, aging and quality of life.

Journal of endocrinological investigation·2005

Same journal

Elevated CK-MB With Normal Total Creatine Kinase Levels in Patients Undergoing Maintenance Hemodialysis-Reply.

Archives of internal medicine·2017

Same journal

Occult Carbon Monoxide Poisoning-Reply.

Archives of internal medicine·2017

Same journal

Acquired Immune Deficiency Syndrome-Reply.

Archives of internal medicine·2017

Same journal

Heparin Side Effects-Reply.

Archives of internal medicine·2017

Same journal

Humanizing primary care medicine begins with stress.

Archives of internal medicine·2017

Same journal

Legend omitted and number misrepresented.

Archives of internal medicine·2013

See all related articles

Excessive thyroid hormone medication can cause bone loss and fractures in women. This condition, known as exogenous hyperthyroidism, may be more common than previously thought due to frequent thyroid medication prescriptions.

Area of Science:

Endocrinology
Bone Metabolism
Pharmacology

Background:

Thyroid hormones are crucial for regulating metabolism.
Thyroid hormone medication is widely prescribed.
Overtreatment can lead to adverse effects.

Observation:

Three women developed osteopenia and subclinical hyperthyroidism while on excess thyroid hormone medication.
Symptoms included mild hypercalcemia, hyperphosphatemia, and hyperphosphatasemia.
Skeletal demineralization and multiple fractures were observed.

Findings:

Bone biopsies revealed accelerated bone turnover, marked osteoclastosis, and significant bone resorption.
These bone changes mirrored those seen in endogenous hyperthyroidism.
Excessive thyroid hormone replacement therapy directly impacted bone health.

Related Experiment Videos

Implications:

Exogenous hyperthyroidism from overtreatment is a potential cause of bone loss.
Clinicians should monitor bone health in patients on thyroid hormone therapy.
Increased awareness may improve diagnosis and management of medication-induced bone disease.