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A fatal case of theophylline intoxication
Archives of Internal Medicine
|March 1, 1983
Summary
This case highlights a fatal theophylline intoxication due to decreased drug clearance. Factors like advanced age, chronic lung/liver disease, and cimetidine use worsened the condition, emphasizing the need for monitoring theophylline levels.
Area of Science:
- Pharmacology
- Clinical Toxicology
- Internal Medicine
Background:
- Theophylline is a bronchodilator with a narrow therapeutic index.
- Theophylline intoxication can lead to severe adverse events and mortality.
- Factors affecting theophylline clearance are crucial for safe administration.