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Related Experiment Videos

Plasma zinc in psoriasis: relation to surface area involvement.

E M McMillan, D Rowe

    The British Journal of Dermatology
    |March 1, 1983
    PubMed
    Summary

    Psoriasis patients with limited skin involvement showed higher plasma zinc levels. Extensive psoriasis correlated with lower zinc, unaffected by albumin or alkaline phosphatase levels.

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    Area of Science:

    • Biochemistry
    • Dermatology
    • Nutritional Science

    Background:

    • Psoriasis is a chronic inflammatory skin condition.
    • Zinc is an essential mineral with roles in immune function and skin health.
    • Previous research suggests potential links between zinc levels and psoriasis severity.

    Purpose of the Study:

    • To investigate plasma zinc levels in patients with psoriasis.
    • To determine if zinc levels correlate with disease severity.
    • To assess the role of serum albumin and alkaline phosphatase in these findings.

    Main Methods:

    • Measured plasma zinc, serum albumin, and alkaline phosphatase in 35 psoriatic patients and matched controls.
    • Compared biochemical parameters between psoriatic patients and controls.
    • Analyzed the relationship between plasma zinc levels and the extent of psoriasis surface involvement.

    Main Results:

    • No overall significant difference in plasma zinc between psoriatics and controls.
    • Psoriatic patients with <10% surface involvement had significantly higher plasma zinc than controls.
    • A negative correlation was observed between psoriasis extent and plasma zinc levels.

    Conclusions:

    • Plasma zinc levels in psoriasis may vary with disease severity.
    • Limited psoriasis involvement is associated with elevated plasma zinc.
    • Albumin and alkaline phosphatase levels do not explain the observed zinc differences.

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