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Updated: Sep 21, 2026

Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays
Published on: March 14, 2011
[Mechanism of lysis by natural killers of target cells infected with Mycoplasma]
Abstract:
NK lymphocytes destroyed target cells contaminated with Mycoplasma to a greater extent as compared with normal cells. The mechanism of that phenomenon is based on the production into the environment by effector lymphocytes cocultivated with contaminated cells of high quantity of mycoplasma that has a non-specific cytolytic effect.
Insights
Natural killer (NK) lymphocytes showed enhanced destruction of Mycoplasma-contaminated cells compared to normal cells. This increased cell killing is attributed to mycoplasma released by effector lymphocytes, which exerts a non-specific cytolytic effect.
Area of Science:
- Immunology
- Microbiology
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