[Effect of exogenous calmodulin on lymphocyte proliferation in healthy individuals]

The action of calmodulin (CM) given in doses of 10(-5)-10(-8) M on lymphocyte proliferation in healthy subjects was studied. All the test doses of CM produced a stimulant effect 72 h after the lymphocyte incubation was commenced. The rate of 3H-thymidine incorporation experimentally was 1.5-3 times higher than in the control. It is assumed that the release of CM in the foci of tissue injury or inflammation may serve one of the factors stimulating lymphocyte proliferation in an individual focus.