[Changes in the primary structure of DNA in rat organs during the aging process]

Biulleten' Eksperimental'Noi Biologii I Meditsiny

|April 1, 1983

Abstract:

Thin-layer chromatography was used to study the composition of bases and pyrimidine sequences of varying lengths (isopliths) in DNA of different organs of rats aged 1, 12 and 30 months. It was found that with age the isoplith composition of DNA in the organs under study changed towards the chaotic distribution. The composition of DNA bases changed with age towards enrichment with guanine-cytosine-vapors, which was particularly pronounced in organs marked by an age-related decrease of 5-methylcytosine in DNA.

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Abstract:

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