[DOCA-salt hypertension in cats]

The possibility of reproducing DOCA-salt hypertension in cats has been explored. It has been shown that administration of DOCA and sodium chloride may result in the development of a hypertensive condition in some of cats. Unilateral nephrectomy increases the probability of hypertension occurrence. To attain a steady and noticeable (up to 190 +/- 8/146 +/- 7 mm Hg) elevation of arterial pressure, it is necessary that appreciable amounts of DOCA and sodium chloride be administered for a long time (during 6 months) in the presence of unilateral nephrectomy. The hypertension thus induced is marked by the increased (71%) overall peripheral resistance and by the decreased cardiac output, which rises for a short period in the course of hypertension development.