Effect of serial seizures on subsequent kindling in the immature brain

The hypothesis that seizures permanently alter the mammalian brain, making it more susceptible to further seizures was tested in the immature rat using the kindling model. Rate of kindling and final kindling stage reached was compared in 30-day-old rats previously subjected to 4 daily electroconvulsive seizures and weight-matched littermate controls. There were no significant differences between the 2 groups. This study does not support the hypothesis that seizures increase susceptibility for further seizures.