The gene family for major urinary proteins: expression in several secretory tissues of the mouse

P H Shaw , W A Held , N D Hastie

Cell +

|

March 1, 1983

View abstract on PubMed

Summary

Major urinary proteins (MUPs) are found in mouse liver and several glands, not just urine. Gene expression varies significantly by tissue and hormonal regulation, suggesting diverse MUP functions.

Area Of Science

Genetics
Molecular Biology
Biochemistry

Background

Major urinary proteins (MUPs) are synthesized in the liver and excreted in urine.
MUPs are encoded by a multigene family at the Mup a locus on mouse chromosome 4.

Purpose Of The Study

To investigate MUP mRNA expression in various secretory tissues.
To analyze the hormonal and developmental regulation of MUP gene expression.
To explore the tissue-specific patterns of MUP mRNA expression.

Main Methods

Analysis of MUP mRNA levels in liver, submaxillary, lachrymal, and mammary glands.
Examination of hormonal and developmental influences on MUP gene expression.
Comparison of MUP mRNA profiles across different secretory tissues.

Main Results

Significant MUP mRNA levels were detected in the liver, submaxillary, lachrymal, and mammary glands.
Hormonal and developmental regulation of MUP gene expression showed striking differences between tissues.
Each tissue exhibited a distinct pattern of MUP mRNA expression, with lachrymal glands expressing a unique set.

Conclusions

MUP gene expression is more widespread in secretory tissues than previously understood.
Tissue-specific regulation and distinct mRNA patterns suggest diverse roles for MUPs beyond urinary excretion.
Further research into the MUP gene cluster organization and protein functions is warranted.

Related Concept Videos