Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions between digoxin and potassium-sparing diuretics.

S Waldorff, P B Hansen, H Egeblad

    Clinical Pharmacology and Therapeutics
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Distribution and risk factors of canine haemotropic mycoplasmas in hunting dogs from southern Italy.

    Veterinary microbiology·2020
    Same author

    Hepatozoon canis in hunting dogs from Southern Italy: distribution and risk factors.

    Parasitology research·2020
    Same author

    Measurements of echocardiographic indices and biomarkers of kidney injury in dogs with chronic kidney disease.

    Veterinary journal (London, England : 1997)·2020
    Same author

    Hereditary factors in peptic ulcer.

    Annals of eugenics·2014
    Same author

    Myogenic tone is impaired at low arterial pressure in mice deficient in the low-voltage-activated CaV 3.1 T-type Ca(2+) channel.

    Acta physiologica (Oxford, England)·2013
    Same author

    Preventing progression to first-episode psychosis in early initial prodromal states.

    The British journal of psychiatry : the journal of mental science·2011
    Same journal

    Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE-Mediated Renal Drug-Drug Interactions in Healthy Volunteers.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug-Drug Interactions for Orforglipron, a Small Molecule Glucagon-Like Peptide-1 Receptor Agonist.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Symposium Report: Stakeholders' Perspectives on Phase 1 Trials in Japanese Prior to Multi-Regional Clinical Trials and Future Pathways.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Resolving CYP2D6 Structural Complexity with Long-Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure.

    Clinical pharmacology and therapeutics·2026
    Same journal

    Risk of Hyperkalemia in Patients with Heart Failure Treated with Spironolactone in Combination with Sacubitril/Valsartan vs. Renin-Angiotensin System Inhibitors.

    Clinical pharmacology and therapeutics·2026
    See all related articles

    Spironolactone and triamterene alter digoxin

    Area of Science:

    • Pharmacology
    • Nephrology
    • Cardiology

    Background:

    • Digoxin is a cardiac glycoside used to treat heart failure and arrhythmias.
    • Its efficacy and safety are influenced by drug interactions affecting its pharmacokinetics and pharmacodynamics.
    • Diuretic use, particularly with potassium-sparing agents, may alter digoxin's effects.

    Purpose of the Study:

    • To investigate the kinetic and hemodynamic interactions of digoxin with spironolactone and triamterene.
    • To explore the influence of these diuretics on digoxin's renal handling and inotropic effects.
    • To elucidate potential mechanisms of drug-receptor interactions.

    Main Methods:

    • Kinetic and hemodynamic studies in six healthy subjects.
    • Administration of digoxin alone, and in combination with spironolactone and triamterene.

    Related Experiment Videos

  • Evaluation of digoxin's positive inotropic effect using systolic time intervals and echocardiography.

    • Main Results:

    • Spironolactone reduced renal tubular secretion and attenuated digoxin's positive inotropic effect.
    • Triamterene decreased extrarenal elimination of digoxin without altering its inotropic effects.
    • Renal handling of digoxin may be influenced by intracellular potassium concentration in renal tubular cells.

    Conclusions:

    • Spironolactone metabolites may interact with digoxin at the digitalis receptor, causing minor inhibition.
    • Triamterene does not affect digoxin's inotropic properties.
    • These findings suggest complex interactions influencing digoxin's therapeutic profile.