Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Azathioprine-associated pulmonary dysfunction.

M J Krowka, R I Breuer, T J Kehoe

    Chest
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Survival in portopulmonary hypertension: Mayo Clinic experience categorized by treatment subgroups.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2008
    Same author

    Liver transplantation for hepatopulmonary syndrome (HPS): what is the MESSAGE?

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2008
    Same author

    How should we treat portopulmonary hypertension?

    The European respiratory journal·2006
    Same author

    Highlights of the ERS Task Force on pulmonary-hepatic vascular disorders (PHD).

    Journal of hepatology·2005
    Same author

    Pulmonary-Hepatic vascular Disorders (PHD).

    The European respiratory journal·2004
    Same author

    Unexplained pulmonary hypertension in chronic myeloproliferative disorders.

    Chest·2001
    Same journal

    The effect of a two-day stay at high altitude (2500 m) on right ventricular afterload and oxygen delivery in patients with pulmonary vascular disease A randomized controlled crossover trial.

    Chest·2026
    Same journal

    A Comparative Study of Radiation Exposure in Conventional and Robotic Bronchoscopy.

    Chest·2026
    Same journal

    Independent Prognostic Contributions of Anti-Ro52 and Anti-MDA5 in Autoimmune-Associated Interstitial Lung Disease.

    Chest·2026
    Same journal

    Lung aeration and gas exchange in SGA or AGA infants with moderate-severe BPD: secondary analysis of the PATH-BPD study.

    Chest·2026
    Same journal

    Lung Cancer Incidence and Mortality after Negative Low-Dose CT Screening Results.

    Chest·2026
    Same journal

    Symptom prevalence and impact on lung cancer risk in the SUMMIT study.

    Chest·2026
    See all related articles

    Azathioprine can cause lung inflammation (alveolitis), even without respiratory symptoms. Gallium-67 scanning and biopsy confirmed this rare side effect, potentially influenced by allopurinol.

    Area of Science:

    • Pulmonary Medicine
    • Immunology
    • Pharmacology

    Background:

    • Azathioprine is an immunosuppressive drug.
    • Drug-induced lung disease is a recognized but uncommon complication.
    • Identifying specific drug triggers is crucial for patient management.

    Observation:

    • A patient presented with unexplained spiking fevers.
    • Chest X-rays were normal, and the patient reported no respiratory symptoms.
    • Azathioprine was being administered as part of the patient's treatment.

    Findings:

    • Diagnosis of azathioprine-associated alveolitis was confirmed using gallium-67 scintigraphy and transbronchial lung biopsy.
    • The patient's concurrent use of allopurinol may have inhibited azathioprine metabolism, potentially contributing to the toxicity.

    Related Experiment Videos

  • This highlights a possible drug interaction exacerbating azathioprine's pulmonary side effects.

    • Implications:

    • Clinicians should consider azathioprine-induced lung disease in febrile patients, even with normal chest imaging.
    • Gallium-67 scanning and biopsy are valuable diagnostic tools for drug-induced alveolitis.
    • Awareness of potential interactions, such as with allopurinol, is important for safe azathioprine prescribing.