The effect of auditory stimulation on epileptogenic electroencephalographic activity

A 24-year-old man with epilepsia generalisata secundaria had a frequency of 5.70 seizures daily and an EEG epileptic activity of 5-15 s/min. Auditory stimulation was administered contingent on epileptogenic activity during daily experimental periods. In comparison to control base-line periods this first resulted in a reduction of seizure duration and thereafter in a reduction in seizure frequency. In a control experiment in which auditory stimulation was provided randomly there was no similar reduction of seizure duration or frequency. At the termination of the experiment the patient's seizure frequency had dropped to 2.66 per day.