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Related Experiment Videos

Modifying factors in urinary bladder carcinogenesis.

N Ito, S Fukushima, T Shirai

    Environmental Health Perspectives
    |March 1, 1983
    PubMed
    Summary
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    N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) induces urinary bladder cancer in animal models. Saccharin promotes this cancer, with effects varying by rat strain, offering insights into human bladder cancer development.

    Area of Science:

    • Oncology
    • Toxicology
    • Carcinogenesis

    Background:

    • N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) is a known animal urinary bladder carcinogen.
    • The BBN model closely mimics human urinary bladder cancer pathogenesis.
    • Understanding factors influencing BBN-induced carcinogenesis is crucial.

    Purpose of the Study:

    • To analyze the histogenesis and morphology of BBN-induced urinary bladder cancer across species and rat strains.
    • To evaluate the role of preneoplastic lesions, specifically papillary or nodular hyperplasia (PN hyperplasia), in two-stage carcinogenesis.
    • To investigate the dose-dependent and organ-specific effects of saccharin as a promoter in BBN-initiated rat urinary bladder carcinogenesis.

    Main Methods:

    • Histogenesis and morphological analysis of BBN-induced bladder tumors in rats, mice, hamsters, and guinea pigs.

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  • Assessment of preneoplastic PN hyperplasia in rat urinary bladders to quantify chemical effects.
  • Two-stage carcinogenesis experiments using BBN as the initiator and various chemicals, including saccharin, as promoters.

    • Main Results:

    • Papillary or nodular hyperplasia (PN hyperplasia) identified as a preneoplastic lesion in rat urinary bladders.
    • Saccharin demonstrated dose-dependent and organ-specific promoting effects on PN hyperplasia after BBN initiation.
    • Significant strain differences in rat urinary bladder susceptibility to saccharin promotion were observed.

    Conclusions:

    • The BBN-induced animal model provides valuable insights into human urinary bladder cancer pathogenesis.
    • Saccharin acts as a promoter in BBN-initiated bladder carcinogenesis, with its effect modulated by dose and genetic factors (rat strain).
    • These findings suggest that similar factors may influence human urinary bladder cancer development.