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The absolute bioavailability of caffeine in man
European Journal of Clinical Pharmacology
|January 1, 1983
Summary
Oral caffeine absorption is rapid and nearly complete in healthy adults. This study found that caffeine
Area of Science:
- Pharmacokinetics
- Human Physiology
Background:
- Caffeine is a widely consumed stimulant.
- Understanding caffeine's oral bioavailability is crucial for dosing and efficacy.
Purpose of the Study:
- To determine the absolute bioavailability of orally administered caffeine.
- To characterize the pharmacokinetic profile of oral caffeine absorption.
Main Methods:
- A randomized crossover study in 10 healthy adult males.
- Caffeine administered orally and intravenously at a 5 mg/kg dose.
- Plasma caffeine levels measured over 24 hours using HPLC.
Main Results:
- Rapid oral absorption with peak plasma concentration at ~30 minutes.
- High maximum plasma concentration (Cmax) with low variability.
- Absolute oral bioavailability was nearly complete (108.3% +/- 3.6%).
Conclusions:
- Oral caffeine is rapidly and almost completely absorbed.
- Significant inter-subject variability exists in caffeine elimination half-life.