Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Considerations in the design of selenium bioavailability studies.

O A Levander

    Federation Proceedings
    |April 1, 1983
    PubMed
    Summary

    Determining human selenium bioavailability requires more than just absorption data. Functional tests measuring the selenoenzyme glutathione peroxidase are more accurate for assessing dietary selenium

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of physical restraint on oxidative stress in mice fed a selenium and vitamin E deficient diet.

    Biological trace element research·2006
    Same author

    Effect of gold(I) compounds on the virulence of an amyocarditic strain of coxsackievirus B3.

    Biological trace element research·2002
    Same author

    Mortality in mice infected with an amyocarditic coxsackievirus and given a subacute dose of mercuric chloride.

    Journal of toxicology and environmental health. Part A·2001
    Same author

    Host nutritional selenium status as a driving force for influenza virus mutations.

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2001
    Same author

    Host selenium status selectively influences susceptibility to experimental viral myocarditis.

    Biological trace element research·2001
    Same author

    Selenium deficiency increases the pathology of an influenza virus infection.

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2001

    Area of Science:

    • Nutritional biochemistry
    • Human metabolism
    • Dietary assessment

    Background:

    • Recent selenium intake recommendations relied heavily on animal data due to limited human studies.
    • Human selenium requirements and bioavailability from various food sources remain incompletely understood.
    • Selenium bioavailability involves absorption and conversion to active forms, which varies by dietary source.

    Purpose of the Study:

    • To evaluate methods for determining human selenium bioavailability.
    • To assess the suitability of functional tests over simple absorption measurements.
    • To investigate the use of selenoenzyme activity as a biomarker for selenium status.

    Main Methods:

    • Comparison of selenium absorption data with functional measures of bioavailability.
    • Utilizing animal models (selenium-depleted rats) to assess dietary selenium's impact on hepatic glutathione peroxidase activity.
    • Exploring platelet glutathione peroxidase activity as a sensitive biomarker in humans.

    Main Results:

    • Selenium absorption alone is insufficient to estimate bioavailability.
    • Hepatic glutathione peroxidase activity restoration varies significantly among different dietary selenium sources in rats.
    • Platelet glutathione peroxidase activity shows promise as a sensitive indicator for human selenium bioavailability studies.

    Conclusions:

    • Functional tests, particularly measuring glutathione peroxidase activity, are superior to absorption assays for assessing selenium bioavailability in humans.
    • Dietary selenium sources differ in their ability to support the synthesis of active selenoenzymes.
    • Platelet glutathione peroxidase activity represents a feasible and sensitive approach for future human selenium bioavailability research.

    Related Experiment Videos