Pseudotumoral enterocolitis and massive eosinophilia

Area of Science:

• Gastroenterology
• Hematology
• Pathology

Background:

• A 23-year-old woman presented with a rare form of enterocolitis.
• The condition was characterized by massive peripheral eosinophilia (up to 60,000/mm³).

Observation:

• Initial symptoms included hemorrhagic colitis, unresponsive to corticosteroids.
• Colectomy provided temporary remission, but the disease recurred in the rectum and small intestine.
• Recurrence involved tumor-like granulomas and eosinophilic infiltration, refractory to treatment.

Findings:

• Despite extensive investigation, no causative agents (parasites, allergens) were identified.
• The localized gut infiltration excluded hypereosinophilic syndrome.
• The enterocolitis did not align with eosinophilic gastroenteritis or other known inflammatory bowel diseases.

Implications:

• This case highlights a previously unreported form of severe enterocolitis.
• The condition presented a diagnostic and therapeutic challenge due to its unique presentation and lack of response to conventional therapies.
• Further research may be needed to understand the etiology and optimal management of such rare gastrointestinal eosinophilic disorders.