Primary aspergillosis of the larynx simulating carcinoma

A case of pseudoepitheliomatous hyperplasia of the larynx secondary to fungal infection is presented. The laryngeal lesion resembled carcinoma both clinically and pathologically. Aspergillus species were identified in tissue sections and confirmed by immunofluorescence studies. The lesion responded well to antifungal therapy. This case is reported because of the extreme rarity of primary aspergillosis of the larynx, its occurrence in an otherwise healthy patient, and its marked resemblance both clinically and pathologically to laryngeal carcinoma.