Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Disease associations with complotypes, supratypes and haplotypes.

R L Dawkins, F T Christiansen, P H Kay

    Immunological Reviews
    |January 1, 1983
    PubMed
    Summary

    Supertypes, combinations of alleles, are linked to diseases like rheumatoid arthritis and diabetes, but their exact role is unclear. Research suggests HLA supratypes may involve immunoregulation, complement, and hormone metabolism in certain autoimmune diseases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A divergent transcriptional landscape underpins the development and functional branching of MAIT cells.

    Science immunology·2019
    Same author

    Clinical and microbiological parameters of naturally occurring periodontitis in the non-human primate <i>Macaca mulatta</i>.

    Journal of oral microbiology·2018
    Same author

    Clinical implications of embryonic wound healing.

    Journal of wound care·2016
    Same author

    Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals.

    Mucosal immunology·2016
    Same author

    Distinct distribution of killer-cell immunoglobulin-like receptor genes in the Mugil and Ilaita areas of Papua New Guinea.

    Tissue antigens·2012
    Same author

    The association of sporadic inclusion body myositis and Sjögren's syndrome in carriers of HLA-DR3 and the 8.1 MHC ancestral haplotype.

    Clinical neurology and neurosurgery·2011

    Area of Science:

    • Immunogenetics
    • Autoimmune Diseases
    • Human Leukocyte Antigen (HLA) Complex

    Background:

    • The term 'supratype' describes combinations of alleles, and their association with diseases like rheumatoid arthritis (RA), insulin-dependent diabetes, myasthenia gravis (MG), and systemic lupus erythematosus (SLE) has been investigated.
    • While supratypes appear significant in RA and diabetes, their precise functional roles remain largely unknown.
    • In MG and SLE, the Human Leukocyte Antigen (HLA) supratype may encompass genetic loci critical for immunoregulation, complement synthesis, and hormone metabolism.

    Purpose of the Study:

    • To explore the role of supratypes, defined as combinations of alleles, in the context of various diseases.
    • To investigate the potential involvement of HLA supratypes in immunoregulation, complement synthesis, and hormone metabolism.
    • To examine the genetic underpinnings of diseases such as sacroiliitis and ankylosing spondylitis (AS), particularly concerning the HLA-B27 locus.

    Related Experiment Videos

    Main Methods:

    • Analysis of allele combinations (supertypes) and their association with specific diseases.
    • Comparison of supratype associations across different autoimmune conditions, including RA, diabetes, MG, SLE, and AS.
    • Examination of the potential role of specific HLA alleles (e.g., Bw35/DR1 vs. A1, B8, DR3) in drug-induced MG.
    • Development of a pathogenetic model for sacroiliitis and AS, postulating the involvement of two non-linked genes acting on HLA-B27.

    Main Results:

    • One or more supratypes appear to be important in RA and insulin-dependent diabetes, though their functional significance is not yet understood.
    • In MG and SLE, the HLA supratype may include loci associated with immunoregulation, complement synthesis, and hormone metabolism.
    • Drug-induced MG shows an association with Bw35/DR1, contrasting with associations typically seen with A1, B8, DR3.
    • No evidence for a supratype was found in AS; instead, a model involving two stepwise acting, non-linked genes influencing HLA-B27 was proposed.

    Conclusions:

    • Supertypes represent a potentially significant factor in the genetic predisposition to certain autoimmune diseases.
    • Further investigation into the functional effects of known loci within the Major Histocompatibility Complex (MHC), especially those related to complement component expression, is warranted.
    • Understanding the genetic architecture beyond single alleles, such as supratypes and interacting genes, is crucial for elucidating disease pathogenesis.