Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Information contained in protein shapes.

K Sundaram, V N Viswanadhan, R D MacElroy

    International Journal of Peptide and Protein Research
    |February 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Barbed sutures reduce arthrotomy closure duration compared to interrupted conventional sutures for total knee arthroplasty: a randomized controlled trial.

    Musculoskeletal surgery·2020
    Same author

    An oxygen-rich atmosphere or systemic fluoxetine extend the time to respiratory arrest in a rat model of obstructive apnea.

    Neurobiology of disease·2019
    Same author

    Diving responses elicited by nasopharyngeal irrigation mimic seizure-associated central apneic episodes in a rat model.

    Neurobiology of disease·2018
    Same author

    Seizure-associated central apnea in a rat model: Evidence for resetting the respiratory rhythm and activation of the diving reflex.

    Neurobiology of disease·2017
    Same author

    Laryngospasm, central and obstructive apnea during seizures: Defining pathophysiology for sudden death in a rat model.

    Epilepsy research·2016
    Same author

    CXCL13 activation of c-Myc induces RANK ligand expression in stromal/preosteoblast cells in the oral squamous cell carcinoma tumor-bone microenvironment.

    Oncogene·2012
    Same journal

    Structure-activity relationship of the ring portion in backbone-cyclic C-terminal hexapeptide analogs of substance P. NMR and molecular dynamics.

    International journal of peptide and protein research·1996
    Same journal

    Conformation of a water-soluble beta-sheet model peptide. A circular dichroism and Fourier-transform infrared spectroscopic study of double D-amino acid replacements.

    International journal of peptide and protein research·1996
    Same journal

    Application of the allyloxycarbonyl protecting group for the indole of Trp in solid-phase peptide synthesis.

    International journal of peptide and protein research·1996
    Same journal

    NMR solution structure of the receptor binding domain of Pseudomonas aeruginosa pilin strain P1. Identification of a beta-turn.

    International journal of peptide and protein research·1996
    Same journal

    Kinetics of inhibition of aminoacylase activity by dithiothreitol or 2-mercaptoethanol.

    International journal of peptide and protein research·1996
    Same journal

    Alanine scan and N-methyl amide derivatives of Ac-bombesin[7-14]. Development of a proposed binding conformation at the neuromedin B (NMB) and gastrin releasing peptide (GRP) receptors.

    International journal of peptide and protein research·1996
    See all related articles

    Protein structure can be analyzed as an informational message using self-information content. This method quantifies structural specificity, revealing intricate patterns and highlighting high potential iron proteins for their unique three-letter dependence.

    Area of Science:

    • Structural biology
    • Bioinformatics
    • Protein structure analysis

    Background:

    • Proteins possess unique local conformational sequences at C-alpha atoms.
    • Understanding these sequences is key to deciphering protein structure and function.
    • Existing methods may not fully capture the intricate details of structural specificity.

    Purpose of the Study:

    • To develop a novel method for quantitating protein structural specificity.
    • To analyze the informational content of protein conformational sequences.
    • To identify unique structural features and dependencies within protein families.

    Main Methods:

    • Treating protein C-alpha atom conformations as an informational message string.
    • Evaluating total self-information content and per-letter self-information.

    Related Experiment Videos

  • Analyzing a dataset of 83 globular proteins with known structures from X-ray crystallography.

    • Main Results:

    • Information content effectively quantifies protein structural specificity.
    • The analysis reveals repeating and intricate structural features.
    • High potential iron proteins exhibit the most significant three-letter sequence dependence among analyzed proteins.

    Conclusions:

    • Self-information content provides a robust metric for protein structural characterization.
    • This approach facilitates the recognition of complex, recurring structural motifs.
    • High potential iron proteins represent a distinct class with notable sequence-structure relationships.