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Tissue mean transit time from dynamic computed tomography by a simple deconvolution technique.

L Axel

    Investigative Radiology
    |January 1, 1983
    PubMed
    Summary
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    This study introduces a simple method to calculate tissue mean transit time using dynamic CT scans. The technique deconvolves contrast material input from tissue enhancement, providing accurate results comparable to existing methods.

    Area of Science:

    • Radiology
    • Medical Imaging
    • Physiology

    Background:

    • Calculating tissue mean transit time (MTT) is crucial for assessing tissue perfusion.
    • Dynamic computed tomography (CT) with contrast material is a common imaging technique.
    • Deconvolution methods are typically used to determine MTT, but can be complex.

    Purpose of the Study:

    • To develop and validate a simplified method for calculating MTT from dynamic CT data.
    • To assess the feasibility of using assumed tissue response curves for MTT calculation.
    • To compare MTT values obtained with this new method to existing literature values.

    Main Methods:

    • Dynamic CT scans were performed after intravenous contrast bolus injection.
    • A deconvolution technique was applied, assuming a specific shape for the tissue's response to contrast.

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  • The width of the best-fitting response curve was used to determine MTT.

    • Main Results:

    • The method successfully calculated MTT in two normal volunteers.
    • Obtained MTT values were comparable to those reported in the literature using other techniques.
    • The technique demonstrated robustness against noise and variations in assumed curve shape.

    Conclusions:

    • A simple and effective method for MTT calculation from dynamic CT is presented.
    • This approach offers advantages in terms of implementation simplicity and noise insensitivity.
    • The method avoids complex curve fitting for recirculation correction.