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Amenorrhea with cryptic hyperandrogenemia.

T J McKenna, A Moore, F Magee

The Journal of Clinical Endocrinology and Metabolism

|May 1, 1983

Summary

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Secondary amenorrhea without hirsutism may indicate hidden androgen excess. Measuring plasma testosterone is crucial for diagnosing amenorrhea, preventing missed cases of hyperandrogenism.

Area of Science:

Endocrinology
Reproductive Medicine
Gynecology

Background:

Current practice assumes clinical signs like hirsutism accompany androgen excess in menstrual disturbances.
Secondary amenorrhea is often evaluated without considering androgen levels if other signs are absent.

Observation:

Three women presented with secondary amenorrhea but lacked typical signs of androgen excess.
These women exhibited elevated plasma testosterone, androstenedione, and estrone levels.

Findings:

Correction of hypertestosteronemia and elevated estrone led to restored ovulation and regular menstruation.
Successful pregnancies were achieved after hormonal correction.

Implications:

Cryptic hyperandrogenism can occur in amenorrhea patients without hirsutism.

Related Experiment Videos

Measuring plasma testosterone is essential in all amenorrhea cases of unknown etiology to detect hidden hyperandrogenism.