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Related Experiment Videos

Atrial transport function in coronary artery disease: relation to left ventricular function.

R I Hamby, W J Noble, D H Murphy

    Journal of the American College of Cardiology
    |April 1, 1983
    PubMed
    Summary

    The atrial contribution to ventricular stroke volume is higher in patients with coronary artery disease compared to healthy individuals. This contribution is inversely related to overall left ventricular function.

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    Area of Science:

    • Cardiology
    • Physiology

    Background:

    • The role of atrial contraction in maintaining cardiac output is significant, particularly in conditions affecting ventricular function.
    • Coronary artery disease (CAD) can impair left ventricular (LV) function, potentially altering the importance of atrial contribution to stroke volume.

    Purpose of the Study:

    • To evaluate the atrial contribution to ventricular stroke volume in patients with coronary artery disease.
    • To determine the relationship between atrial contribution to stroke volume and left ventricular function in these patients.

    Main Methods:

    • Fifty patients with coronary artery disease underwent comprehensive hemodynamic and angiographic assessments.
    • Angiographic volume studies were used to quantify atrial contribution to stroke volume, end-systolic volume, and ejection fraction.

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  • Comparisons were made with a control group of 11 healthy individuals.

    • Main Results:

    • Patients with coronary artery disease exhibited a significantly higher atrial contribution to stroke volume (33% +/- 11%) compared to normal subjects (20% +/- 7%).
    • Congestive heart failure and cardiomegaly were associated with the highest atrial contribution (46%).
    • Atrial contribution showed a strong inverse correlation with left ventricular ejection fraction (r = -0.64) and end-systolic volume (r = 0.56).

    Conclusions:

    • Atrial contribution to stroke volume is significantly increased in patients with coronary artery disease.
    • This increased atrial contribution is inversely related to left ventricular function, highlighting its compensatory role in compromised ventricles.