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Antigenic cross-reactions between woodchuck hepatitis virus and human hepatitis B virus shown by immune electron
The Journal of General Virology
|April 1, 1983
Abstract:
Using immune electron microscopy (IEM), low-level cross-reactions could be demonstrated between the surface antigens of hepatitis B and woodchuck hepatitis. However, immune complex formation was greatly enhanced by pre-exposure of the antigens to 0.5% deoxycholate. Cross-reaction between the core antigens and e antigens of both viruses was also confirmed by IEM as well as radioimmunoassay. It appears that the woodchuck sera used in this study may well contain an anti-immunoglobulin akin to rheumatoid factor.
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