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The great circulatory paradox.

D Short

    Lancet (London, England)
    |June 11, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Infarction without arterial blockage is common in the brain and gut, but rare in the heart and legs. Arterial blockages without infarction are frequent across all four areas, highlighting factors beyond atherosclerosis.

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    Area of Science:

    • Cardiovascular Medicine
    • Neurology
    • Gastroenterology

    Background:

    • Infarction and arterial obstruction are critical clinical events.
    • Understanding their relationship is key to effective treatment and prevention.
    • Atherosclerosis is a commonly assumed cause of infarction.

    Purpose of the Study:

    • To review the relationship between infarction and arterial obstruction.
    • To investigate infarction without arterial stenosis across brain, gut, leg, and heart.
    • To explore causes of arterial occlusion without infarction.

    Main Methods:

    • Literature review of studies on infarction and arterial obstruction.
    • Analysis of data across four major vascular territories: brain, gut, leg, and heart.

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  • Identification of factors contributing to infarction without demonstrable arterial stenosis.

    • Main Results:

    • Infarction without arterial stenosis is common in the brain and gut, but rare in the heart and legs.
    • Arterial occlusion without infarction is common in all four vascular territories.
    • Embolism, spasm, and acute circulatory failure are key causes of infarction without stenosis.

    Conclusions:

    • Factors beyond atherosclerosis play a significant role in infarction etiology.
    • Cerebral embolism and coronary spasm are increasingly recognized causes.
    • A comprehensive understanding of infarction causes is crucial for prevention and treatment strategies.