Dissolution of a soluble drug substance from vinyl polymer matrices

It was shown that vinyl polymers form good bases for in vitro sustained-release matrices, and that the character of the release curves is basically in line with their pH-solubility profiles. For a flow cell, the release curves may be approximated by the equation: In (m/m0) = - K(t -ti), where m is the amount not dissolved, m0 is the initial drug content, K is a dissolution constant, t is time, and ti is a lag time. Furthermore, it was shown that K is a function of tablet hardness (H) and polymer content (Q, percent). This functionality is well represented by the equation: In K = alpha H + gamma ln Q + epsilon, where alpha, gamma, and epsilon are polymer-dependent parameters. Matrix erosion is represented by an exponential decay: (p/p0) = exp(-Dt + a), where p is the amount not eroded, p0 is the initial weight, D is an erosion constant, and a is a soluble polymer-dependent parameter. In the case of these soluble polymers, K is not solely a function of D.