Hypogonadism and massive testicular infiltration due to amyloidosis

We report a case of infertility with bilateral testicular enlargement and hypogonadism due to amyloidosis. Testicular biopsy revealed complete replacement with amyloid and subsequent investigation demonstrated primary hypogonadism with marked elevation of gonadotropins, azoospermia, mild renal failure and lack of progression of generalized amyloidosis during 2 years.