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Related Experiment Videos

Esophageal impaction in BHE rats.

Z Ruben, E Rohrbacher, J E Miller

    Laboratory Animal Science
    |February 1, 1983
    PubMed
    Summary

    Spontaneous esophageal impaction, a condition causing esophageal dilation and blockage, was observed in BHE rats. This finding highlights esophageal myodegeneration as a potential cause in aged rats.

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    Area of Science:

    • Veterinary Pathology
    • Gastroenterology
    • Animal Models

    Background:

    • Spontaneous esophageal impaction is a rare condition in animals.
    • Previous research has not extensively documented this condition in Brown Norway rats.

    Purpose of the Study:

    • To characterize the clinical and pathological findings of spontaneous esophageal impaction in Brown Norway rats (BHE rats).

    Main Methods:

    • Observation of 157 BHE rats aged 6 to 26 months that died or were euthanized.
    • Clinical assessment of affected rats, including duration and symptoms.
    • Gross and histological examination of the esophagus.

    Main Results:

    • Spontaneous esophageal impaction occurred in 33 rats.
    • Clinical signs included weakness, excessive salivation, and head movements, lasting less than 48 hours.
    • Esophageal dilation (up to 7.0 mm) with impacted material was observed, predominantly in the caudal esophagus, with associated myodegeneration.

    Conclusions:

    • Spontaneous esophageal impaction is a significant condition in aged BHE rats.
    • Esophageal myodegeneration is a key pathological finding associated with this condition.
    • Further research is warranted to explore the underlying mechanisms and potential treatments.

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