Periodic acid-Schiff positive deposits associated with aging in mouse brains

Deposits which were heavily stained with periodic acid-Schiff's solution were observed in a serial study of mouse brain section. Their histochemical reactions to ferric acid, calcium, glycogen, amyloid, and mucopolysaccharide were negative. Many deposits were observed within 100 microns from the midline of the dorsal part of the ventral thalamic nucleus. The deposit sizes were directly related to the age of the mice (r2 = 0.99).