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Aldosterone 21-sulphate in man.

T P Jowett, J D Slater

    Journal of Steroid Biochemistry
    |April 1, 1983
    PubMed
    Summary

    Aldosterone 21-sulphate is found in higher concentrations in adrenal veins than peripheral blood. This compound exhibits minimal mineralocorticoid activity and is irregularly excreted, with a significant unidentified metabolite.

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    Area of Science:

    • Endocrinology
    • Steroid Biochemistry

    Background:

    • Aldosterone is a key mineralocorticoid regulating blood pressure.
    • The metabolic pathways and physiological significance of aldosterone metabolites are not fully understood.

    Purpose of the Study:

    • To investigate the presence and activity of aldosterone 21-sulphate.
    • To characterize its excretion and metabolism in humans.

    Main Methods:

    • Radioimmunoassay for aldosterone 21-sulphate measurement.
    • In vitro incubation of adrenal tissue.
    • Mineralocorticoid activity assay in adrenalectomized rats.
    • Chromatographic characterization of metabolites after administering radiolabeled aldosterone 21-sulphate.

    Main Results:

    • Aldosterone 21-sulphate concentrations are higher in adrenal veins than peripheral plasma.
    • Adrenal glands and adenomata produce aldosterone 21-sulphate in vitro.
    • Peripheral plasma concentrations are approximately 10% of aldosterone.
    • Mineralocorticoid activity is less than 1% of aldosterone.
    • Excretion of [3H]-aldosterone 21-sulphate is irregular, with a major unidentified metabolite.

    Conclusions:

    • Aldosterone 21-sulphate is a significant metabolite produced by the adrenal gland.
    • It possesses low mineralocorticoid activity.
    • Its metabolism involves an unidentified compound, suggesting novel biochemical pathways.

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