Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Low doses of X-rays decrease the risk of diploidy in mouse oocytes.

I Hansmann, J Jenderny, H D Probeck

    Mutation Research
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    MECHANISMS OF NONDISJUNCTION AND IMPLICATIONS FOR TESTING ANEUGENS.

    Biologisches Zentralblatt·2018
    Same author

    Phenotype-genotype correlations in patients with Marinesco-Sjögren syndrome.

    Clinical genetics·2013
    Same author

    FXIII deficiency due to base exchange Thr 449 (ACT) --> Ile (ATT) in exon 11 of the factor 13A gene. A cause of bleeding?

    Hamostaseologie·2010
    Same author

    The 9p24.3 breakpoint of a constitutional t(6;9)(p12;p24) in a patient with chronic lymphocytic leukemia maps close to the putative promoter region of the DMRT2 gene.

    Cytogenetic and genome research·2009
    Same author

    [Severe prekallikrein deficiency due to a compound heterozygosis in the KLKB1-gene].

    Hamostaseologie·2009
    Same author

    20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits.

    Journal of medical genetics·2008
    Same journal

    Monoallelic germline RAD51C, RAD51D, and BRIP1 variants in hereditary cancer testing: Variant spectrum and clinical counselling implications.

    Mutation research·2026
    Same journal

    Prediction of hepatocellular carcinoma associated biomarkers in TP53 gene; A comprehensive in silico analysis.

    Mutation research·2026
    Same journal

    IDH1 mutation promotes angiogenesis via upregulation of hypoxia inducible factor 1 alpha in glial tumors.

    Mutation research·2026
    Same journal

    Targeting overexpressed oncogenes in esophageal cancer through miRNA-mediated gene silencing: Insights from binding affinity and thermodynamic profiling.

    Mutation research·2026
    Same journal

    The active compound quercetin from Polygonum cuspidatum targets COL3A1 to enhance CD8⁺ T cell cytotoxicity in gastric cancer.

    Mutation research·2026
    Same journal

    E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT.

    Mutation research·2026
    See all related articles

    Low-dose X-ray exposure significantly reduced diploid oocytes in mice, but higher doses reversed this effect. This suggests radiation directly impacts gonadotrophin-induced aneuploidy, not through secondary mechanisms.

    Area of Science:

    • Reproductive biology
    • Radiation biology
    • Mouse models

    Background:

    • NMRI/Han mice ovulate approximately 12% diploid oocytes after gonadotrophin stimulation.
    • Diploid oocytes can lead to the development of triploid embryos upon fertilization.

    Purpose of the Study:

    • To investigate the effect of preovulatory X-ray exposure on the incidence of diploid oocytes in gonadotrophin-primed mice.
    • To determine the dose-response relationship of X-ray irradiation on diploid oocyte production.

    Main Methods:

    • NMRI/Han mice were primed with gonadotrophins and exposed to varying doses of X-rays (0.05-0.80 Gy) during the preovulatory period.
    • The percentage of diploid oocytes was assessed post-ovulation.

    Main Results:

    Related Experiment Videos

    • X-ray doses from 0.05 to 0.40 Gy significantly decreased the percentage of diploid oocytes.
    • A dose of 0.80 Gy resulted in a diploid oocyte incidence similar to that of unirradiated controls.
    • A negative hump-shaped dose-response curve was observed for diploid oocyte incidence.

    Conclusions:

    • The observed effect is likely due to direct radiobiological interference of low X-ray doses, protecting against gonadotrophin-induced aneuploidy.
    • The results do not support secondary modifications like selective killing of diploid oocytes or compensatory super-ovulation as the cause.