Related Experiment Video
Updated: Aug 14, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Administration of meptazinol to opiate-dependent patients
Abstract:
A double blind comparison of the effect of intravenous meptazinol 100 mg and placebo was carried out on 8 opiate-dependent patients who were on a prolonged methadone withdrawal regime. Psychological and physiological measurements revealed no significant differences between meptazinol and placebo, and no patient reported pleasurable effects following meptazinol injection. These findings support the evidence from animal studies that meptazinol is unlikely to be abused by opiate addicts or to lead to dependence.
Related Concept Videos
CNS Depressants: Barbiturates and Benzodiazepines
Opioid Receptors: Overview
Analgesia and Pain Management
Opioid Analgesics: Morphine and Other Natural Cogeners
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...

