[Calcitonin and paratirin in nodular pathology of the thyroid gland]

The calcitonin-parathyroid hormone secretion (CPS) ratio was studied by means of radioimmunoassay in different cases of nodose thyroid pathology. It was found that functional thyroid reconstruction induces un balance of calcitropic hormones. The development of "hot", functionally active nodes is accompanied by CPS lowering due to disturbed parathyroid hormone secretion. "Cold" nodes produce no disorder in the calcitropic hormone ratio in relative insufficiency of thyroid function. However, a marked shift towards an increase in calcitonin secretion and a decrease in parathyroid hormone level occur in malignant "cold" thyroid nodes. CPS is enhanced in adenocarcinoma and is maximum in medullary cancer.