Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phencyclidine and behavior: II. Active avoidance learning and radial arm maze performance.

R P Kesner, J D Hardy, J M Novak

    Pharmacology, Biochemistry, and Behavior
    |March 1, 1983
    PubMed
    Summary

    Phencyclidine (PCP) impairs rats

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cord blood thyroxine and thyroid stimulating hormone screening for congenital hypothyroidism: how useful are they?

    Journal of pediatric endocrinology & metabolism : JPEM·2008
    Same author

    Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F.

    Journal of cell science·1999
    Same author

    The first lung transplant in man (1963) and the first heart transplant in man (1964).

    Transplantation proceedings·1999
    Same author

    Technical options in venous valve reconstruction.

    American journal of surgery·1997
    Same author

    Back then--plus ten commandments for graduates with illustrative cases.

    Journal of the Mississippi State Medical Association·1993
    Same author

    Single- and double-lung transplantation. Problems and possible solutions.

    Annals of surgery·1990

    Area of Science:

    • Neuroscience
    • Behavioral Pharmacology

    Background:

    • Phencyclidine (PCP) is a dissociative drug known for its complex effects on the central nervous system.
    • Understanding PCP's impact on cognitive functions is crucial for both clinical and research purposes.

    Purpose of the Study:

    • To investigate the specific cognitive deficits induced by phencyclidine (PCP) in rats.
    • To determine if PCP impairs learning and memory encoding processes.

    Main Methods:

    • Rats were administered phencyclidine (PCP) at doses of 4 or 8 mg/kg.
    • Cognitive performance was assessed using active avoidance learning and radial arm maze tasks.

    Main Results:

    • PCP administration significantly impaired active avoidance learning and radial arm maze performance.
    • The deficits were not attributable to sensory or motor impairments.
    • Evidence suggests PCP disrupts the encoding of task-relevant attributes, including context, response selection, and emotional components.

    Conclusions:

    • Phencyclidine (PCP) primarily affects the cognitive processes involved in encoding information during learning tasks.
    • These findings highlight PCP's disruptive effects on memory formation and contextual understanding.

    Related Experiment Videos