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Diazepam dose preference in humans.

M L Healey, R W Pickens

    Pharmacology, Biochemistry, and Behavior
    |March 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Human subjects showed varied diazepam dose preferences, particularly when pentobarbital was the alternative. Individual and time-of-day factors influenced self-administered diazepam dosage selection.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Behavioral Science

    Background:

    • Understanding drug dose preference is crucial for optimizing patient outcomes and adherence.
    • Diazepam, a commonly prescribed benzodiazepine, has a wide therapeutic range, making dose selection important.
    • Previous research has not fully elucidated the factors influencing self-selected diazepam doses.

    Purpose of the Study:

    • To investigate human subjects' dose preference for diazepam when offered a choice against a standard compound.
    • To explore how different standard compounds (diazepam or pentobarbital) and their doses affect diazepam selection.
    • To examine individual variability and temporal changes in diazepam dose preference.

    Main Methods:

    • Ten human subjects participated in a hospital-based study.

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  • Subjects had ad libitum access to select between a standard compound (diazepam or pentobarbital) and various diazepam doses (2-40 mg/capsule).
  • Dose preference was assessed under different standard conditions and across different times of day.

    • Main Results:

    • No clear diazepam dose preference emerged when 5 or 10 mg/capsule diazepam was the standard.
    • A clear diazepam dose preference was observed in some subjects when 30 or 50 mg/capsule pentobarbital was the standard.
    • Significant inter-subject variability in dose preference function shape and intra-subject variability within a day were noted.

    Conclusions:

    • Pentobarbital as a standard significantly influenced diazepam dose selection in some individuals.
    • Diazepam dose preference is a complex behavior influenced by the alternative drug, individual factors, and time of day.
    • Further research is warranted to understand the neurobiological and psychological underpinnings of benzodiazepine dose selection.