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Related Experiment Videos

Stimulation parameters influence response involvement in reinforcing brain stimulation.

P A Mason, A Laferrière, P M Milner

    Physiology & Behavior
    |January 1, 1983
    PubMed
    Summary
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    Rats learned to terminate brain stimulation by navigating a T-maze. This behavior, driven by an aversive effect of stimulation, depended on temporal parameters and neural activity buildup.

    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Animal Behavior

    Background:

    • Self-stimulation (SS) paradigms are used to study reward pathways.
    • Experimenter-administered stimulation (EAS) can be used to probe behavioral responses to predictable or unpredictable stimulation.

    Purpose of the Study:

    • To investigate how temporal parameters of brain stimulation influence behavior in a T-maze task.
    • To examine the role of stimulation-induced neural activity in mediating avoidance behavior.

    Main Methods:

    • Rats were trained to press a lever for brain stimulation in a T-maze.
    • Stimulation was delivered under self-stimulation (SS) and experimenter-administered stimulation (EAS) conditions.
    • Temporal parameters of stimulation (intertrain interval, train duration) were manipulated.

    Related Experiment Videos

  • The effect of omitting stimulation during EAS periods was assessed.

    • Main Results:

    • Manipulating temporal density of stimulation affected the latency to terminate EAS.
    • Omitting stimulation during EAS periods disrupted learned avoidance behavior.
    • Behavioral responses were influenced by the summated neural activity from stimulation trains.

    Conclusions:

    • Avoidance behavior in this paradigm is linked to an aversive component of rewarding brain stimulation.
    • The buildup of neural activity, influenced by stimulation parameters, plays a critical role in mediating this behavior.
    • Behavioral adaptation to stimulation schedules is dependent on the continuity of stimulation delivery.