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Vulnerability and immune response. An overview.

L A Gottschalk, W D Welch, J Weiss

    Psychotherapy and Psychosomatics
    |January 1, 1983
    PubMed
    Summary
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    Depression and hostility can impair immune function. In a small study, depressed subjects showed reduced polymorphonuclear neutrophil immune response, suggesting a link between psychological state and host defense mechanisms.

    Area of Science:

    • Immunology
    • Psychoneuroimmunology
    • Cellular Biology

    Background:

    • Infections and neoplasms may arise from inadequate immune system recognition or response to foreign invaders.
    • Psychosocial factors are increasingly implicated in modulating host defenses against infectious and neoplastic diseases.
    • The immune system's competency is crucial for maintaining health and combating disease.

    Purpose of the Study:

    • To explore the relationship between depressive reactions and the immune function of polymorphonuclear neutrophils.
    • To investigate if psychological distress impacts specific cellular immune responses.
    • To understand the immunologic underpinnings of the mind-body connection in disease.

    Main Methods:

    • An exploratory study involving 7 human subjects experiencing depressive reactions.

    Related Experiment Videos

  • Assessment of immune function using the chemiluminescence assay for polymorphonuclear neutrophils.
  • Comparison of immune response in depressed subjects versus nondepressed healthy controls.

    • Main Results:

    • The 3 most depressed and/or hostile subjects exhibited significant inhibition of normal polymorphonuclear neutrophil immune response.
    • This immune inhibition, measured by chemiluminescence, was notably lower in depressed individuals.
    • No significant differences in pharmacologic agents, plasma cortisol levels, or circadian rhythms accounted for the observed immune suppression.

    Conclusions:

    • Depressive reactions and hostility may be associated with impaired polymorphonuclear neutrophil immune function.
    • This finding suggests a potential immunologic mechanism linking psychological distress to compromised host defenses.
    • Further research is warranted to elucidate the psychoneuroimmunological pathways involved in disease susceptibility.