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Related Experiment Videos

Mebendazole concentrations in sheep plasma.

C A Behm, R A Cornish, C Bryant

    Research in Veterinary Science
    |January 1, 1983
    PubMed
    Summary

    Mebendazole administered to sheep showed dose-dependent plasma concentrations, with peak levels occurring 9-24 hours post-treatment. Two major metabolites were consistently detected at higher concentrations than mebendazole itself.

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    Area of Science:

    • Veterinary Pharmacology
    • Pharmacokinetics
    • Anthelmintic Drug Metabolism

    Background:

    • Mebendazole is a broad-spectrum anthelmintic used in livestock.
    • Understanding its pharmacokinetic profile in sheep is crucial for effective treatment.
    • Information on mebendazole metabolism and excretion in sheep is limited.

    Purpose of the Study:

    • To determine the plasma concentrations of mebendazole and its metabolites in sheep.
    • To investigate the dose-dependent pharmacokinetic behavior of mebendazole.
    • To characterize the metabolic profile of mebendazole in ovine plasma.

    Main Methods:

    • Sheep were administered mebendazole via intraruminal injection at varying dose rates (12.5-100 mg/kg).
    • Plasma samples were collected over 48 hours post-administration.
    • High-performance liquid chromatography (HPLC) was used to quantify mebendazole and its metabolites.

    Main Results:

    • Peak plasma concentrations of mebendazole ranged from 0.22 to 0.76 microM across the tested dose rates.
    • Peak concentrations were observed between 9 and 24 hours, with rapid decline thereafter.
    • Two major metabolites were consistently detected, exceeding mebendazole concentrations at all dose rates.

    Conclusions:

    • Mebendazole exhibits dose-dependent pharmacokinetics in sheep.
    • The rapid decline and high metabolite concentrations suggest extensive metabolism.
    • Further studies are warranted to identify the specific metabolites and their activity.

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