Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endogenous pyrogen activity in human plasma after exercise.

J G Cannon, M J Kluger

    Science (New York, N.Y.)
    |May 6, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Oxidative burst intensity of peripheral phagocytic cells and periodontitis in Down syndrome.

    Journal of periodontal research·2013
    Same author

    Phagocytic cell activity and periodontitis in Down syndrome.

    Oral diseases·2011
    Same author

    Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of Gulf War illness.

    Toxicology and industrial health·2003
    Same author

    Modulation of body temperature, interleukin-6 and leptin by oral contraceptive use.

    Neuroimmunomodulation·2002
    Same author

    Role of capsaicin-sensitive afferents in fever and cytokine responses during systemic and local inflammation in rats.

    Neuroimmunomodulation·2001
    Same author

    Influence of barometric pressure on interleukin-1 beta secretion.

    American journal of physiology. Regulatory, integrative and comparative physiology·2001
    Same journal

    Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

    Science (New York, N.Y.)·2026
    Same journal

    Local signals, systemic decline.

    Science (New York, N.Y.)·2026
    Same journal

    The mechanics of liver regeneration.

    Science (New York, N.Y.)·2026
    Same journal

    Computing in a memory with physics.

    Science (New York, N.Y.)·2026
    Same journal

    Retraction.

    Science (New York, N.Y.)·2026
    Same journal

    Making time.

    Science (New York, N.Y.)·2026
    See all related articles

    Exercise releases endogenous pyrogen, a fever-inducing protein, into the bloodstream. This substance elevates body temperature and lowers iron and zinc levels in rats, mimicking infection responses.

    Area of Science:

    • Exercise physiology
    • Immunology
    • Trace metal metabolism

    Background:

    • Exercise can induce physiological changes similar to infection.
    • Endogenous pyrogen is a key mediator of fever and trace metal regulation during infection.

    Purpose of the Study:

    • To investigate if exercise releases endogenous pyrogen.
    • To determine the effects of exercise-induced factors on body temperature and trace metal levels.

    Main Methods:

    • Human plasma and leukocytes from post-exercise subjects were used.
    • Injections into rats and in vitro incubations were performed.
    • Body temperature and plasma trace metal concentrations (iron, zinc) were measured.

    Main Results:

    Related Experiment Videos

  • Exercise plasma elevated rat rectal temperature and decreased plasma iron and zinc.
  • The pyrogenic factor was heat-denaturable with a molecular weight of 14,000 daltons.
  • Leukocyte-released factors mimicked these effects on rats.

    • Conclusions:

    • Endogenous pyrogen is released into circulation during human exercise.
    • Exercise-induced endogenous pyrogen influences thermoregulation and trace metal metabolism.
    • This suggests a link between exercise, fever mediators, and metabolic responses seen in infection.