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Podophyllin poisoning. Systemic toxicity following cutaneous application.
Obstetrics and Gynecology
|July 1, 1978
Summary
Topical podophyllin toxicity caused coma and organ damage in a teenager. Charcoal hemoperfusion therapy resolved acute toxicity, though peripheral neuropathy persisted.
Area of Science:
- Dermatology
- Toxicology
- Pharmacology
Background:
- Podophyllin is a topical agent used for treating warts.
- Systemic absorption and toxicity are rare but serious complications.
Observation:
- A 16-year-old girl experienced severe toxicity after topical podophyllin application.
- Symptoms included coma requiring respiratory support, neurological deficits, hematologic abnormalities, and hepatic dysfunction.
Findings:
- Charcoal hemoperfusion was employed as a novel treatment modality.
- This therapy successfully resolved the acute systemic toxicity.
- A persistent peripheral neuropathy was noted 4 months post-treatment.
Implications:
- Highlights the potential for severe systemic toxicity from topical podophyllin.
- Demonstrates the efficacy of charcoal hemoperfusion in managing podophyllin poisoning.
- Underscores the need for cautious use and monitoring of topical podophyllin, especially in younger patients.