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Amoxapine intoxication in an infant: seizures arrested with diazepam
Southern Medical Journal
|April 1, 1983
Insights
A 15-month-old infant experienced severe seizures after amoxapine ingestion. Standard treatments failed, but diazepam eventually controlled the seizures, though the child later died.
Area of Science:
- Pediatric Toxicology
- Neuropharmacology
- Antidepressant Poisoning
Background:
- Amoxapine is a novel tricyclic antidepressant.
- Tricyclic antidepressant overdose can cause severe neurological and cardiovascular toxicity.
- Infant and child poisoning cases are critical for understanding drug toxicity.
Abstract:
A 15-month-old infant had hyperpyrexia and severe generalized seizures without cardiovascular toxicity after the ingestion of 250 mg of amoxapine, a new tricyclic antidepressant of the dibenzoxapine subclass. The seizures failed to respond to physostigmine or the usual anticonvulsant therapies, but were controlled after eight hours by a second administration of diazepam. The child died 144 hours after amoxapine ingestion.